Un refuerzo con la vacuna estadounidense Pfizer contra el coronavirus aumentó hasta 20 veces el nivel de anticuerpos en personas inmunizadas con el esquema completo de la china Coronavac, según resultados preliminares de un estudio realizado en Uruguay, donde el 24% de la población ya recibió tres dosis contra el COVID-19.
Desde principios de marzo, científicos del Institut Pasteur (IP) de Montevideo y la Universidad de la República (Udelar) llevan adelante un proyecto de investigación para estudiar la evolución de los niveles de anticuerpos específicos contra el SARS CoV2 en relación con las vacunas y dosis administradas.
El estudio, que involucra a más de 200 voluntarios, durará dos años y prevé hacer extracciones de sangre periódicas a los participantes.
A un primer subgrupo de 57 personas que ya recibió tres dosis contra el COVID-19 se les extrajo sangre en cuatro ocasiones: antes de ser vacunados, a los 18 días y luego 80 días promedio de recibida la segunda dosis de Coronavac, y 18 días promedio después de la tercera dosis de Pfizer.
En el primer muestreo, ninguno de los participantes mostró anticuerpos específicos contra el SARS CoV2, algo esperable ya que ninguno había contraído el virus.
En el segundo, el 100% mostró presencia de anticuerpos específicos anti-virales, pero con niveles variables.
Tras la tercera extracción, se encontró un descenso global de anticuerpos respecto a los niveles hallados en el segundo muestreo.
Y finalmente, tras la tercera dosis, se constató que todos los participantes presentaron un aumento en el nivel de anticuerpos que en promedio fue 20 veces superior al encontrado en el segundo muestreo.
«Son resultados preliminares, en una población particular«, aclaró este viernes en conferencia de prensa Sergio Bianchi, investigador del IP.
Los científicos continuarán con el seguimiento para saber por cuánto tiempo se mantendrán los niveles de anticuerpos anti-virales posteriormente a la vacunación. También esperan aumentar la cantidad de participantes analizados.
Uruguay con 3,5 millones de habitantes cuenta con el 72% de su población vacunada con el esquema completo de Coronavac, Pfizer o Astrazeneca, en tanto el 24% ya ha recibido una tercera dosis de refuerzo. AFP
Por Agencia
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